Overexpression of phospholipase D suppresses taxotere-induced cell death in stomach cancer cells
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منابع مشابه
Synergistic Effects of NDRG2 Overexpression and Radiotherapy on Cell Death of Human Prostate LNCaP Cells
Background: Radiation therapy is among the most conventional cancer therapeutic modalities with effective local tumor control. However, due to the development of radio-resistance, tumor recurrence and metastasis often occur following radiation therapy. In recent years, combination of radiotherapy and gene therapy has been suggested to overcome this problem. The aim of the current study was to e...
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Vitamin C is generally thought to enhance immunity and is widely taken as a supplement especially during cancer treatment. Tamoxifen (TAM) has both cytostatic and cytotoxic properties for breast cancer. TAM engaged mitochondrial oestrogen receptor beta in MCF-7 cells and induces apoptosis by activation of pro-caspase-8 followed by downstream events, including an increase in reactive oxygen spec...
متن کاملPhospholipase D in cell proliferation and cancer.
Phospholipase D (PLD) has emerged as a regulator of several critical aspects of cell physiology. PLD, which catalyzes the hydrolysis of phosphatidylcholine (PC) to phosphatidic acid (PA) and choline, is activated in response to stimulators of vesicle transport, endocytosis, exocytosis, cell migration, and mitosis. Dysregulation of these cell biological processes occurs in the development of a v...
متن کاملOverexpression of Cytosolic Group IVA Phospholipase A2 Protects Cells from Ca2+-dependent Apoptotic Cell Death*
The calcium ionophore ionomycin induces apoptosis-like events in the human embryonic kidney (HEK) cell line at early times. Plasma membrane blebbing, mitochondrial depolarization, externalization of phosphatidylserine and nuclear permeability changes can all be observed within 15 min of treatment. However, there is no activation of caspases or chromatin condensation. Expression of a fusion prot...
متن کاملHonokiol suppresses survival signals mediated by Ras-dependent phospholipase D activity in human cancer cells.
PURPOSE Elevated phospholipase D (PLD) activity provides a survival signal in several human cancer cell lines and suppresses apoptosis when cells are subjected to the stress of serum withdrawal. Thus, targeting PLD survival signals has potential to suppress survival in cancer cells that depend on PLD for survival. Honokiol is a compound that suppresses tumor growth in mouse models. The purpose ...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
سال: 2008
ISSN: 0167-4889
DOI: 10.1016/j.bbamcr.2007.11.019